The Federal Circuit affirmed the District of Massachusetts's grant of summary judgment invalidating all claims of Enanta Pharmaceuticals' U.S. Patent No. 11,358,953 as anticipated by Pfizer's prior public disclosure of nirmatrelvir, the active ingredient in Paxlovid®. The central issue was whether Enanta's non-provisional application, which issued as the '953 patent and disclosed a substituent containing "—NHC(O)—C₁-C₁₂-alkyl" (one to twelve carbon atoms), could claim priority to an earlier provisional application that disclosed "—NHC(O)—C₂-C₁₂-alkyl" (two to twelve carbon atoms). Enanta argued the provisional contained an obvious typographical error that would have been apparent to a person of ordinary skill in the art, thus providing adequate written description support under 35 U.S.C. § 112 for the later-filed claims. The Federal Circuit held that the provisional application did not satisfy the written description requirement because it specifically disclosed only C₂-C₁₂ alkyl, not C₁ alkyl, and the disclosure of "2" cannot provide written description support for "1"—even if other portions of the provisional arguably contained inconsistencies. Because the '953 patent could not claim the provisional's July 2020 priority date, Pfizer's April 2021 disclosure of nirmatrelvir anticipated the claims.
The decision reinforces that written description support for priority purposes requires actual disclosure in the earlier application, not what might be inferred from purported errors elsewhere in the specification. The court distinguished this case from traditional genus-species written description disputes like Ariad and In re Ruschig, and from cases concerning judicial or PTO correction of errors in issued patents under Novo Industries and In re Oda, instead applying the straightforward requirement that each application in a priority chain must describe the claimed invention with sufficient detail to demonstrate possession. The court rejected expert testimony suggesting that a typographical error in a general definition of "alkyl" elsewhere in the provisional could establish written description support for a specific substituent, emphasizing that extrinsic evidence cannot vary plain patent language and that entitlement to a filing date extends only to what is actually disclosed. The analogy to ethanol versus methanol underscores the court's unwillingness to read disclosure of one specific chemical integer as inherently disclosing another, even structurally adjacent compounds, absent explicit textual support.